Indonesia Jurnal Kebidanan
HUBUNGAN KADAR RESISTIN MATERNAL DAN FETAL PADA IBU OBESITAS DAN NORMAL TERHADAP ANTROPOMETRI BAYI BARU LAHIR
Abstract
Obesitas dan Status gizi berlebih mempengaruhi pertumbuhan janin. Obesitas mengalami peningkatan lemak sehingga meningkatkan beberapa adipokin salah satunya resistin. Resistin berperan dalam menjaga homeostasis glukosa dengan menginduksi resistensi insulin, antiadipogensis dan inflamasi. Resistin ditemukan dalam tali pusar bayi sehingga resistin dapat berperan dalam pertumbuhan janin. Tujuan dari penelitian ini adalah untuk mengevaluasi perbedaan kadar resistin maternal antara ibu obesitas dan berat badan normal serta hubungannya dengan antropometri bayi baru lahir. Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Subjek terdiri dari 20 orang ibu obesitas dan 20 orang berat badan normal. Pengambuilan sampel dilakukan dengan consecutive sampling di RSUP Dr. M. Djamil Padang, RSUD dr. Rasidin Padang dan RS TK III Reksodiwiryo Padang, Indonesia. Sampel darah diukur dengan spektrofotometri. Statistik dianalisis dengan Uji Mann Whitney U-Test dan Uji Spearman. Median resistin maternal pada subjek obesitas dan berat badan normal adalah 1406(1024,31-1947,78)ng/L dan 1308,46 (740,16-1521,56) ng/L (p<0,05). Median resistin fetal pada subjek obesitas dan berat badan normal adalah 1086,47 (820,09-2205.29)ng/L dan 1077,59 (704,65-1654,76) ng/L (p>0,05). Terdapat hubungan kadar resistin maternal dengan berat badan bayi baru lahir dengan r=-0,412 (p<0,05). Terdapat hubungan kadar resistin fetal dengan berat badan bayi baru lahir dan panjang badan bayi ( r=-0,649, dan r=-0,455) (p<0,05). Kadar resistin mempengaruhi pertambahan berat badan janin pada kelompok obesitas dan berat badan normal.
Kata Kunci: Resistin Maternal, Resistin Fetal, Antropometri Bayi Baru Lahir, Obesitas.
Full Text:
PDFReferences
Avagliano, L. Garo, C. And Marconi, AM. (2012). Placental Amino Acids Transport In Intrauterine Growth Restriction. Italy: Hindawi Publishing Corporation Journal Of Pregnancy. Journal Of Pregnancy. pp. 1-6.
Benomar, Y. Gertler, A. De Lacy, P. Crepin, D. Hamouda, HO. Roffault, L. et al. (2013). Central Resistin Overexpossure induces insuli resistance through Toll-Like 4 Receptor 4. France: Diabetes Journal.. pp. 102-144.
Blackburn, ST. (2013). Maternal, Fetal & Neonatal Physiology : A Clinical Perspective. Elsevier.
Briana, DD and Punchner, M.A. (2009). Intrauterine Growth Restriction And Adult Disease: The Role Of Adipocytokines. Greece: European Journal Of Endocrinology. pp. 337-347.
Buller, CL. (2010). Role Of GLUT1 In The Mammalian Target Of Rapamycin Pathway: Machanism Of Regulation. Dissertation. Molecular and Integrative Physiology University. Michigan.
Challier, JC. Basu, S. Bintein, T. Hotmire, K. Minium, J. Catalano, PM. et al. (2008). Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Paris: NIH Public Acces. pp. 274-281.
Cortelazzi, D. Corbetta, S. Ronzoni, S. Pelle, F. Marconi, A. Cozzi, V. et al. (2008). Maternal And Foetal Resistin and adiponecin Concentrations In Normal nad Complicated Pregnancies. Italy: Blackwell Publishing.pp. 447-453.
Dung-Fang, L. Hsu-Ping, K. Chun-Te, C. Jung-Mao, H. Chao-Kai, C. Yongkun, W. et al. (2007). IKKb Suppression of TSC1 Links Inflammation and Tumor Angiogenesisvia the mTOR Pathway. Elsevier Inc.pp. 440-455.
Duran, RV and Hall, MN. (2012). Regulation of TOR by small GTPases. Switzerland: European Molecular Biology Organization. pp. 121-128.
Farid, SD. Najati, N. Gharebaghi, MM. Haghjo, AG. Ghojazadeh M. (2012). Resistin in Cord Blood of Small for Gestation Age and Appropriate for GestationAge Term Neonates. Iran: Tehran University Of Medical Science. pp 659-663.
Lissauer T & fanaroff A. (2009). At a Glance Neonatologi. Erlangga. Jakarta.
Fatouhikia, S. Pourarian, S. Javanmardi, H. Setoodehnia, Z and Saki, F. (2016). Investigating the Association of Cord Blood Resistin and Birth Weight in Term and Preterm Neonates. Iran: Int Journal Of Pediatrica.pp.3769-75.
Fernandez, CM. Acro, AD. Gallardo, N. Aguado, L. Rodriguez, M. Ros, M. et al. (2013). S-Resistin Inhibits Adipocyte Diffrentiation And Increase TNFα Expression And Secretion In 3T3-L1 Cells. Spain: Biochimica Et Biophysica Acta pp. 1131-1141.
Fitter, S. Matthews, M.P. Martin, SK. Jianling, X. Soo, S.O. Walkley, C.R. et al. (2016). mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Ustralia: American Society For Microbiology.
Geum, JC. Sang, WY. Soon, CH. Min-Jeong, OH. Tak, K. Hai, JK. Et al. (2006). Correlations between umbilical and maternal serum resistin levels and neonatal birth weight. Korea: Acta Obstetria et Gynecologica. pp. 1051-1056.
Gaccioli F, Lager S, Powell T, and Jansson T. ( 2013). Placental Transport in Response to Altered Maternal Nutrition. Texas: NIH Public Acces. pp. 101-115.
Hehai, P. Xiang, L. Jianru, W. Kuibo, Z. Hao, Y. Zerni, L. (2015). LIM Mineralization Protein-1 Enhances Bone Morphogenetic Protein-2–Mediated Osteogenesis Through Activation of ERK1/2 MAPK Pathway and Upregulation of Runx2 Transactivity. China: Jounrnal Of Bone And Mineral Research. pp 1523-1535.
Huanbin, H. Liping, X. Aimei, W. Jiashi, G. Huihui, K. Yungzhong, Y. Xiaoning, Y. (2016). Correlation of resistin expression in maternal serum and subcutaneous adipose tissue with insulin resistance in gestational diabetes mellitus. China: Int J Clin. pp. 18721-18727.
Hyeong, KP and Ahima, RS. (2013). Resistin in Rodents and Humans. Revie Obesity and Metabolic syndrome. Korea: Diabetic Metabolism Journal Seoul. pp.404-414.
Jing, W. Li-Xin, S. Xing, D. Xin, W. Nan, W. Shu-se, W. (2010). Relationship of adiponectin and resistin levels in umbilical serum, maternal serum and placenta with neonatal birth weight. Australian And New Zealand: Journal Of Obstetrica And Gynecology. pp. 432-438.
Jones, HN. Jansson, T and Powell, TL. (2009). IL-6 stimulates system A amino acid transporter activity in trophoblast cellsthrough STAT3 and increased expression of SNAT2. Ohio: American Physiological Society. pp. 1228-1235.
Jyh, KN. Shali, MT. Romero, R. Kusanovic, JP. Erez, O. Gotsch, F. et al. (2007). Resistin : A Hormone Which Induces Insulin Resistance Is Increased In Normal Pregnancy. New York: Journal Perianatology Med. pp. 513-512.
Karatas, A. Issikent, NT. Ozlu, T and Demirin, H. (2014). Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus. United Kingdom: Gynecological Endocrinology. pp. 1473-0766.
Kementrian Kesehatan Indonesia tahun 2015 “Renstra Kesehatan Indonesia 2015-2019” Jakarta.
Laplante, M and Sabatini, D. (2012). mTOR signaling in growth control and disease. Canada: NIH Public Acces. pp. 274-293.
Marfianti, E. (2006). Perbedaan Kadar Resistin Pada Obes Dengan Resistensi Insulin Dan Obes Tanpa Resistensi Insulin. Jurnal Kedokteran Dan Kesehatan Indonesia.
Megia, A. Vandrell, J. Gutierrez, C. Sabate, M. Brosch, M. Fernandez-Real, JM. et al. (2008). Insulin Sensitivity and Resistin Levels In Gestational Diabetes Mellitus And After Parturition. European Journal Of Endocrinology. pp. 173-178.
Norwood, AK. (2013). Maternal Obesity Alters Fetal Development Due To Impaired Placental Function And Has Lasting Effects On Adult Offspring. Thesis. University Of Nebraska. Nebraska.
Noureldeen, A.F. Qusti, S.Y. And Al-seeni. M. (2014). Serum Leptin, Adiponectin, Resistin, Visfatin and Inflammatory Cytokines in Normal Weight and Obese Women with Normal Pregnancy and with Preeclampsia. Life Science Journal.
Pak-Cheng, NG. Cheuk, L. Christopher, WK. Lam, I. Chan, EW. Tai, F. et al. (2006). Resistin in Preterm and Term Newborns: Relation to Anthropometry, Leptin, and Insulin. USA: International Pediatric Research Foundation.
Robert, K.A. Riley, S.C. Reynolds, R.M. Barr, S. Evans, M. Statham, A. et al (2011). Placental Structure And Inflammation In Pregnancies Associated With Obesity. Elsevier Journal. pp. 247-254.
Sadler, TW. (2012). Embriologi Kedokteran Langman. Edisi 12. Jakarta: EGC.
Simon, ND. Nicuolo, FD. Marzioni, D. Castellucci, M. Sanguinetti, M. D’lppolto, S. et al. (2009). Resistin modulates glucose uptake and glucose transporter-1 (GLUT-1) expression in trophoblast cells. Italy: Blackwell Cellular and Molecular Medicine. pp. 388-397.
Un, JJ and Myung-Sook, C. (2015). Obesity And Its Metabolic complications: The Role Of Adipokines And The Relationship Between Obesity, Inflammation, Insulin Resistance, Dyslipidemia And Nonalcoholic Fatty Liver Disease. International Journal Of Molecular Science. pp. 6184-6223.
Vernini, JM. Moreli, JB. Antonio, R. Negrato, CA. Cunha, MV. Caldero, IM. (2016). Maternal Adipokines And Insulin As Biomakers Of Pregnancy Complicated By Overweight And Obesity. Brazil: Diabetology & Metabolic Syndrome. pp.1-68.
Viengsakhone, L. Yoshida, Y. Or-Rashid, H & Sakamoto, J. (2010). “Factors Affecting Low Birth Weight” At Four Central Hospitals In Vientine, Lao Pdr, Journal Nagoya med. pp. 51-58.
Yuan, L. Cheng-Yuan, S. Shan-Shan,W. Qiu-Hua, L. Ling-Qing, Y. Er-Yuan,L. (2013). Novel Adipokines And Bone Metabolism.
Yoshito, I. Hiroyuki, T. Susuma, H. Kazuaki, K and Kentaro, K. (2013). Resistin Affects Lipid Metabolism During Adipocyte Maturation Of 3T3-L1 Cells. Japan : The FEBS Journal. pp.5884-5895.
DOI: https://doi.org/10.26751/ijb.v2i2.564
Refbacks
- There are currently no refbacks.
Indonesia Jurnal Kebidanan indexed by
Published by LPPM Universitas Muhammadiyah Kudus
Jl. Ganesha Raya No.I, Purwosari, Kec. Kota Kudus, Kabupaten Kudus, Jawa Tengah 59316
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.